According to this study's bioinformatics analysis, the 10 most important genes that HCM and COVID-19 have in common are THBS2, BGN, COL1A2, ACTA2, MYH11, AEBP1, ISLR, FRZB, MFAP4, and LOXL1. Each of these hub genes is essential for various functional mutation developments. This evidence concerns the gene COL1A2 and COVID-19.