In this study, we integrated 13 NPC datasets, including 308 NPC samples and 66 noncancer controls from four countries, which have the characteristics of multiple samples and centers; we applied comprehensive analysis to obtain the conclusion that ARNT2 mRNA was upregulated in NPC; then, we further explored the potential molecular mechanism of ARNT2: analyze the pathways where dysregulated target genes related to ARNT2 and in NPC were enriched. Here, ARNT2 is linked to nasopharyngeal carcinoma.