Similar to our finding, Shen et al. adopted the method of bioinformatics to explore expression profile chip data from Gene Expression Omnibus (GEO) and the RNAseq tertiary dataset from TCGA database of HNSCC, three key genes (TGFBI, SPP1, and LAMB3) related to HNSCC prognosis were identified [55]. The gene discussed is TGFBI; the disease is head and neck squamous cell carcinoma.