Furthermore, MAP2K1 overexpression reversed the inhibitory effects of miR-34c-5p mimic on GC cell proliferation, invasion, and migration, and conversely, MAP2K1 interference reversed the promotive effects of miR-34c-5p inhibitor on GC cell proliferation, invasion and migration (Figure 4(b)–4(d)). Here, MAP2K1 is linked to gastric cancer.