MAP2K1 and hepatocellular carcinoma: Cui et al. found that overexpression of miR-539 inhibited cell proliferation, migration, invasion and promoted apoptosis, thus inhibiting the progression of hepatocellular carcinoma, and this oncogenic function of miR-539 was accomplished by directly targeting and regulating MAP2K1 [33], Zhou et al. found that MAP2K1 is also a target for miR-149-5p, and miR-149-5p can regulate the proliferation, migration and invasion of hepatocellular carcinoma cells by targeting MAP2K1 [34].