Through KEGG pathway analysis, we screened out kernel pathways such as a tumor, prostate cancer, PI3K-Akt signaling pathway, Ras signaling pathway, thyroid hormone signaling pathway, prolactin signaling pathway, pancreatic cancer, and FoxO signaling pathway, indicating that the underlying mechanisms of PCB interference in thyroid hormone dysfunction are mainly concentrated in the tumor, inflammation, and hormone levels. This evidence concerns the gene PRL and familial pancreatic carcinoma.