TERF1 and cancer: The KEGG pathway enrichment analysis also demonstrated that the target genes of tRF-1:29-Pro-AGG-1-M6 and tRF-55:76-Tyr-GTA-1-M2 were mainly enriched in cancer-related signaling pathways, including the metabolic pathway, pyrimidine metabolism, MAPK signaling pathway, calcium signaling pathway, and HIF-1 signaling pathway (Figure 6E).