NQO1 and cancer: In our study, we found that exposure of NQO1+ cancer cells to KP372-1 alone caused PARP1 hyperactivation and NAD+/ATP depletion, and cells underwent autophagy and capase-7 dependent apoptosis, while exposure of these cells to KP372-1 + PARP inhibitor rucaparib induced elevated ROS formation and inhibition of DNA repair resulting in rapidly autophagic and apoptotic cell death (Figures 2G, H, 4E, 5B–E, and Figures S2E–G).