Indeed, ten-eleven translocation (TET) enzyme-mediated locus-specific CpG demethylation decreased in chicken embryos treated with the glutaminase inhibitor bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl) ethyl sulfide (BPTES) under dynamic conditions of TET induction, although it should be noted these studies were not conducted in the setting of cancer (46). The gene discussed is GLS; the disease is cancer.