CDA and cancer: In particular, as the most involved member of this family in the cancer pathophysiology process, APOBEC3B limits viral reverse transcriptase by editing complementary DNA (cDNA) intermediates by relying on the action of cytidine deaminase (26), and it is also involved in promoting the biological occurrence and evolution of cancer through its role as a dependent or independent cytidine deaminase in the immune microenvironment (6, 11, 27).