APOBEC3B is the most common member of the family, and it is involved in the development of cancer, including liver cancer (5), breast cancer (6), gastric cancer (7), chondrosarcoma (8), kidney cancer (9), colorectal cancer (10), cervical squamous cell carcinoma (11), lung cancer (12), and bladder cancer (13). The gene discussed is APOBEC3B; the disease is liver cancer.