MGMT and central nervous system cancer: We found that clustering of gliomas was significantly related to patients’ age at diagnosis, WHO grade, IDH mutational status, 1p19 codeletion status, Alpha Thalassemia Developmental Delay (ATRX) mutational status, O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status, and telomerase reverse transcriptase (TERT) promoter mutational status, but not gender (Figures 3A–H).