The analysis showed significantly higher CD8+ scores in patients without bone metastasis compared to patients with bone metastasis (hotspot score: 1573 ± 386 cells/mm2 vs. 323 ± 82 cells/mm2, p = 0.003; average score: 640 ± 200 cells/mm2 vs. 161 ± 47 cells/mm2, p = 0.025) (Figures 3A–C; Table 4), suggesting a potential role of CD8+ T cells in suppressing bone metastasis. Here, CD8A is linked to bone metastasis.