The identification of a single nucleotide polymorphism (rs1061170—Y402H) in FH as a major susceptibility factor for AMD178, 179, 180, 181, 182, 183 and strong association of variants in complement genes, including CFB, CFI, and C3, with AMD has confirmed a role for the AP/AL. The gene discussed is FH; the disease is age-related macular degeneration.