FH deficiency in man67, 68 and pigs69 leads to almost complete C3 consumption, due to lack of control on the AL; with FH deficiency linked to several disease conditions including systemic lupus erythematosus (SLE),70 meningococcal disease,70 familial hemolytic uremic syndrome,67 DDD,68 glomerulopathy71 and glomerulonephritis/IgA Nephropathy70 as well as porcine MPGN type II.69 The gene discussed is C3; the disease is systemic lupus erythematosus.