Further dietary studies in C57BL/6 mice and in vitro analysis of the murine 3T3‐L1 cell line revealed that FD promotes adipocyte differentiation and lipid accumulation through the C3a‐C3aR signaling pathway171 showing that, although FD may not be the predominant driver of obesity, it still has a clear role in metabolic activity. The gene discussed is ELP1; the disease is obesity due to melanocortin 4 receptor deficiency.