C4A and age-related macular degeneration: Although patients with AMD do exhibit higher serum levels of activation products C3d, Ba, C3a, C5a, SC5b‐9; C3, C4, FB, and FD, allowing for a systemic impact of genetic changes on AMD, local complement activation and the correct regulation of that activated complement are being described as critical to disease progression.175, 184, 185, 186