Percent change of 4 proteins (GPVI, PAI-1, tissue factor, CD40LG) differed in T2D subjects at baseline to hypoglycemia between deep-hypo (study-2) and mild-hypo (study-1); three proteins (GPVI, PAI-1, tissue factor) were higher in response to deep-hypo and one (CD40LG) was higher in response to mild-hypo in T2D subjects. This evidence concerns the gene SERPINE1 and type 2 diabetes mellitus.