Deep-hypo increased the %change of the following proteins in T2D: GPVI (16.8 ± 6.5 vs. -10.0 ± 7.7%change of GPVI at hypoglycemia, study-2 vs. study-1, p = 0.02) (Fig. 3 A); PAI-1 (27.0 ± 13.4 vs. -6.2 ± 27.1%change of PAI-1 at hypoglycemia, study-2 vs. study-1, p = 0.05) (Fig. 3B); Tissue factor (-4.5 ± 3.3 vs. -21.8 ± 10.61%change of Tissue factor at hypoglycemia, study-2 vs. study-1, p = 0.05) (Fig. 3 C). Here, GP6 is linked to type 2 diabetes mellitus.