Deep-hypo increased the %change of the following proteins in control subjects: PAI-1 (101.1 ± 38.4 vs. -37.5 ± 17.3%change of PAI-1 at hypoglycemia, study-2 vs. study-1, p = 0.03) (Fig. 2 A); CD40LG (5.7 ± 3.4 vs. -25.8 ± 9.0%change at hypoglycemia, study-2 vs. study-1, p = 0.0006) (Fig. 2B); protein S (1.0 ± 2.3 vs. -10.7 ± 5.3, %change at hypoglycemia, study-2 vs. study-1, p = 0.03) (Fig. 2 C). This evidence concerns the gene PROS1 and Hypoglycemia.