NPM1 and acute myeloid leukemia: Therefore, ASXL1, SRSF2, DNMT3A, and EZH2 mutations commonly concur in all types of TET2MT myeloid malignancies, while splicing factor mutations (e.g., SF3B1 and SRSF2) more commonly occur in MDS and MDS/MPN cases, JAK2, CBL, and N-RAS kinase mutations more commonly occur in MPN and MDS/MPN cases, NPM1, FLT3-ITD, JAK2, CBL, c-KIT, and isolator mutations are more common in AML (Fig. 3A).