In de novo AML, higher frequencies of NPM1, DNMT3A, CEBPA, ZRSR2, ASXL1, and N-RAS mutations were observed in TET2MT cases compared to TET2WT cases, while FLT3-ITD, FLT3-TKD, JAK2, RUNX1, CEBPA, CBL, KIT, SMC3, CBL, EZH2, and CUL mutations are comparable between TET2MT and TET2WT cases [154, 155]. This evidence concerns the gene RUNX1 and acute myeloid leukemia.