Compared to TET2WT MDS/MPN and MPNs, a higher frequency of SRSF2, ASXL1, RUNX1, CBL, JAK2, N-RAS, and SF3B1 mutations were observed in TET2MT MDS/NPM, whereas a higher frequency of JNK2, ASXL1, SRSF2, TET2, CBL, SETBP1, N-RAS, and EZH2 mutations were seen in TET2MT MPNs. The gene discussed is EZH2; the disease is myelodysplastic syndrome.