LINC00467 can also directly regulate downstream protein-coding genes, thereby promoting the occurrence and development of breast cancer via TGF-β2, lung adenocarcinoma via EZH2, and gastric cancer via ITGB3, etc. In addition, LINC00467 was found to play a regulatory role in the NF-κB signaling pathway, Wnt signaling pathway and AKT signaling pathway (Fig. 4). This evidence concerns the gene ITGB3 and lung adenocarcinoma.