All inherited thrombophilia defects were associated with venous thromboembolic disease (VTE), homozygous/ heterozygous FV G1691A and FII G20210A were associated with pregnancy loss < 24 weeks [Odds ratio (OR) 2.71, 1.68, 2.49 respectively], heterozygous FV G1691A, FII G20210A, and PS with pregnancy loss > 24 weeks (OR 2.06, 2.66, 20.09), heterozygous FV G1691A and FII G20210A with PE (OR 2.19, 2.54), and heterozygous FV G1691A and FII G20210A with PA-VTE (OR: 4.70, 7.71). Here, F5 is linked to Rare hereditary thrombophilia.