Additionally, it has been shown that SSRI used to treat depression reduce levels of pro-inflammatory cytokines, including interleukin-1α (IL-1α), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-12 (IL-12), and IFN-γ [30]. Here, CXCL8 is linked to major depressive disorder.