Through additional protein-protein interactions that recalibrate protein phosphorylation, FKBP51 also impacts signaling of other depression-relevant pathways such as GSK3β [103], BDNF [102, 104], and nuclear factor kappa B, linking it to inflammation and the immune system [105, 106], as well as autophagy [107, 108]. This evidence concerns the gene GSK3B and major depressive disorder.