Importantly, ASM/ceramides are linked to synaptic activity and pathways that had been associated with MDD before: these include TRPC6 and thus growth cone guidance, spine morphology, dendritic outgrowth and neuronal survival [248], as well as PKC and regulation of tubulin, GSK-3β, and β-catenin [67]. This evidence concerns the gene TRPC6 and major depressive disorder.