After combining the two methods and ROC analysis, eight NSCLC-related biomarkers with accurate predictive properties were identified (the AUCs of all these eight genes were greater than 0.89), including ADAMTS8, ABCA8, TPX2, CEP55, ASPA, FHL1, RAMP3, and PYCR1 genes. The gene discussed is ASPA; the disease is non-small cell lung carcinoma.