SPINK1 and posterior cortical atrophy: To establish the accurateness and reliability of employing EREG/ CXCL8 for in vivo SASP appraisal, we selectively captured stromal cells from the primary tissues of PCa patients via LCM, and analyzed the levels of a subset of typical SASP factors, including but not limited to IL6, GM-CSF, IL1α, IL-1β, IL7, WNT16B, SPINK1 and MMPs (Fig. 7f).