It is noticeable that expression of some SASP factors such as MMP3 and MMP12, together with the canonical senescence markers including p16INK4A and p21CIP1, was induced by MIT in both stromal and cancer cells, suggesting chemotherapy caused comprehensive in vivo senescence, although the SASP profile seemed to be differently developed between these two cell populations (Fig. 6c and Supplementary Fig. 7e). This evidence concerns the gene CDKN1A and cancer.