Indeed, high EREG expression in the microenvironment is found to be correlated with advanced pathological stages, cancer cell invasion, distant metastasis, shorter OS and DFS of diverse cancer types including oral squamous cell carcinoma, gastric cancer, glioblastoma, colorectal and non-small cell lung cancer [11, 12, 68–71], supporting EREG one of the competent targets for anticancer therapies. Here, EREG is linked to cancer.