Multiple infections of intestinal parasites with HIV are common in most tropical and sub-tropical countries and are associated with common risk factors such as rural residence, lack of education, promiscuous defecation, lack of potable water, etc. HIV infection is the most common immunodeficiency condition with the hallmark of depleting CD4+ T lymphocytes which are essential components of the cell-mediated immune system thus exposing HIV persons to possibly multiple intestinal parasitic infections. The gene discussed is CD4; the disease is HIV infectious disease.