Administration of SPT-siRNA soon after induction of diabetes prevented an increase in SPT in diabetic mice on normal diet or high fat diet (Diab/SPT-si and HF-SD/SPT-si groups, respectively), and the values in these two groups were not different from those obtained from mice in Norm group (p > 0.05 vs Norm). The gene discussed is AGXT; the disease is diabetes mellitus.