One of the strongest cell-composition-mediated effects of CMV infection was observed in an intron of DNMT3A (β value scale 95% confidence interval [CI]: [1.8%, 2.4%], Padj = 1.1 × 10−23), encoding a key DNA methyltransferase playing a role in the replication of some herpesviruses38. Here, DNMT3A is linked to cytomegalovirus infection.