Confirming previous findings53,67, the strongest sex-by-age interaction effects were found at FIGN (Padj < 7.1 × 10−15), associated with risk-taking behaviors68 and educational attainment69, and PRR4 (Padj < 5.6 × 10−3), associated with the dry eye syndrome, a hormone-dependent, late-onset disorder70. The gene discussed is PRR4; the disease is dry eye syndrome.