The results in Fig. 9c indicated that LEN exhibited comparable EC50 values across these cell lines, which suggested the following possibilities: i) LEN readily displaces CPSF6 from HIV-1 cores; or ii) LEN can interact with HIV-1 cores at unoccupied hydrophobic CA pockets without displacing pre-bound CPSF6 and thereby inhibit infection. This evidence concerns the gene CPSF6 and infection.