We present here our findings that delineate how TrkC as oncogene induces the acquisition of CSC traits and chemoresistance via activation of the EMT program by inhibiting degradation of DJ-1, which is one of the key prognostic markers of neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease and various cancer types, including HCC [17, 18]. The gene discussed is PARK7; the disease is cancer.