NTRK3 and hepatocellular carcinoma: To address this question, TrkC was knocked down or overexpressed via a pLenti-TrkC plasmid or short hairpin RNA to generate SNU387 HCC cell lines lacking the expression of the TrkC protein and PLC/PRF/5 cell lines overexpressing the corresponding protein (data not shown) and then determine whether the loss or gain of TrkC expression could regulate the growth of HCC cells.