After cancer cells have passed through the EMT program, these cells enhance the malignancies by inducing and maintaining their populations of CSC through induction of EMT-TFs, such as Snail, Slug, SIP-1, Gosecoid, ZEB1, Foxc1, Foxc2, Twist-1, and Twist-2 involved in activation of EMT program through the autocrine signaling and other diverse stimuli [4, 46]. The gene discussed is FOXC2; the disease is cancer.