POU5F1 and hepatocellular carcinoma: We next examined increased TrkC expression forced to arising and maintaining CSCs via inducing pluripotent embryonic stem cell markers such as Oct4, Nanog, SOX2, and CSC surface markers (CD133, CD90, CD117, and CK19) of HCC, which are essential for self-renewal, metastasis, recurrence, chemoresistance of CSC [6, 28–31].