In particular, genes associated with immune regulation or immune response were upregulated in these three clusters from ITP, such as IGKC, CTSZ, and LYZ in preB3, IGKC, LYZ and PTPRC in preB1, and IL32, CD48, and B2M in NK/Tp (Fig. 4c and Supplemental Fig. 4a, b). This evidence concerns the gene CTSZ and autoimmune thrombocytopenic purpura.