Results indicated that RRM2 was highly expressed in bladder, breast, colorectal, gastric, liver, kidney, lung, lymphoma tumors, etc. Also, its high expression was associated with OS, DFS, and PFI in ACC, KICH, KIRC, KIRP, LGG, LIHC, LUAD MESO PAAD, and SARC in the TCGA project. The gene discussed is RRM2; the disease is adrenal cortex carcinoma.