In additionto the cellular components described above, the TME contains a multitude ofnoncellular components that form the extracellular matrix (ECM) including laminin,hyaluronan, collagen, and fibronectin (54).Throughout the development of the tumor, there exists strong, reciprocalcommunication between the tumor and the TME, including both cell–cell andcell–ECM interactions. This evidence concerns the gene FN1 and neoplasm.