It was also enriched on serum-derivedEVs relative to unfractionated serum (30).When compared with healthy controls, glypican-1 was significantly increased in serumexosomes inpatients with pancreatic cancer, and research suggested it could be usedfor early detection of the disease with very high diagnostic sensitivity andspecificity (126). This evidence concerns the gene GPC1 and familial pancreatic carcinoma.