In recent years, studies confirmed that NLRP3 inflammasome is activated during several cardiac disorders, and NLRP3 inflammasome‐mediated pyroptosis aggravates pressure overload‐induced cardiac hypertrophy, fibrosis, dysfunction,6 which is a key pathological factor underlying HF.7, 8, 9. The gene discussed is NLRP3; the disease is cardiac hypertrophy.