GSDMD and gastric cancer: For instance, downregulation of the expression of inflammasomes mediating pyroptosis led to the cell proliferation, while downregulation of GSDMD significantly facilitated the cell proliferation of gastric cancer, but in heart, the expression of inflammasomes and GSDMD all elevated and induced cardiomyocytes pyroptosis and subsequently led cardiac hypertrophy, fibrosis, apoptosis, inflammation and dysfunction.6, 26