In the present study, we found that ECH down‐regulated phosphorylation levels of SAPK/JNK, the activation of JNK mediated cardiac hypertrophy, apoptosis, interstitial fibrosis, remodelling and dysfunction and inhibited the activation of JNK can protect against cardiac remodelling.30, 31, 32, 33, 34. The gene discussed is MAPK8; the disease is cardiac hypertrophy.