The protein markers of pyroptosis in left ventricular tissue of rats were tested by WB, the results revealed that the expression of cleaved caspase‐1, caspase‐1, the ratio of cleaved caspase‐1/caspase‐1, NLRP3, IL‐1β, IL‐18, GSDMD‐N and ASC were significantly up‐regulated in HF rats induced by ISO, and obviously, ECH reversed the changes and down‐regulated the expression of these proteins, as shown in Figure 1G–L. The gene discussed is IL18; the disease is hydrops fetalis.