Inaddition, there is clear evidence that the inhibition of boththe isoforms VA and VB leads to considerable weight loss.11,20,21 Given these considerations, DPPIV and CA (II and V) can be considered good targets to treat concomitantlyT2DM and obesity, which are often linked. The gene discussed is DPP4; the disease is obesity due to melanocortin 4 receptor deficiency.