Given therelevance of dipeptidyl peptidase IV (DPP IV) and carbonic anhydraseisoforms II and V (CAs II and V) roles in the pathology of T2DM aswell as in the weight loss, multitarget ligands able to modulate theseenzymes could represent a promising therapeutic approach for antidiabesitytreatment. This evidence concerns the gene DPP4 and type 2 diabetes mellitus.