We found that the average nucleus size of proliferating cells was dramatically increased in LAs (Normal, 7.64 ± 0.04 μm, EGFR, 11.4 ± 0.12 μm, KRAS, 11.1 ± 0.12 μm error SEM, p = 2.5 x 10−69), suggesting that these enlarged cells are not senescent but are contributing to tumor growth (Fig 7A, S23 and S24 Figs). This evidence concerns the gene KRAS and neoplasm.