Kaplan-Meier survival analysis (http://kmplot.com/analysis) showed that high RAD21 expression was associated with worse progression-free survival (P = 0.0011) (Supplemental Figure 1B) (31), and especially correlated with poor prognosis in the early stage of HGSOC (P = 0.0031) (Supplemental Figure 1C), suggesting that RAD21 may drive tumor initiation in HGSOC. This evidence concerns the gene RAD21 and neoplasm.