NF2 and meningioma: In the British study,5 2 meningioma cases occurred among individuals with genetic syndromes, both of which were NF2.21 In both studies,5,7 presence of any genetic syndrome was not associated with a higher risk of meningioma and did not significantly change the radiation dose-response.8,21 While uncommon and therefore unlikely to have had a major impact on our risk estimates,22 more detailed and systematic measurement of predisposition syndromes could provide deeper insight into this question.