Similarly, the 42 common downregulated TFs (Figure 4B) include both signatures of steatosis and obesity (CNOT3, CREB3L3, REPIN1, STAT1), and signatures of fibrosis (CCNE1, ETS1, HDAC6, HDAC9, HLF, PLAGL1, SOX4, TRIM16, TRIM29) and hepatocellular carcinoma (HCC) (BCL3, MYCBP, SMARCA4). The gene discussed is STAT1; the disease is steatosis.