Furthermore, the performance was also significantly worse than that for the non-cancer predictions (Figure 2E-G, Supplementary Figure S2B, ‘Cancer on ChemPert’ and ‘ChemPert’, respectively), indicating that the cancer database can give better predictions for cancer cells than the non-cancer database and that the increased performance for non-cancer cells based on the non-cancer database is not due to the higher number of unique perturbagens in the database but rather due to the higher similarity in response TF profiles. The gene discussed is TF; the disease is cancer.