ID2 and Hepatic fibrosis: Others are ID2, which reduces differentiation of HSCs and thus inhibits liver fibrosis (46), RUNX1, which regulates the expression of angiogenic and adhesion molecules, enhancing inflammation and disease severity in NASH (47), and KLF2, which has been reported to be elevated in livers from obese mice, and to induce triglycerides accumulation (48).