On the other hand, the GSEA of 376 common down-regulated TFs (Figure 4D, Supplementary Table S2) included the Interferon gamma (IFN-γ) signalling, which has previously shown promising results in terms of fibrosis scores in patients with chronic HBV infection, most likely by antagonizing profibrogenic transforming TFG-β effects (40); and in accordance with these data, a preclinical IFN-γ deficient model showed a rapid development of liver fibrosis when fed a fatty diet (41). Here, IFNG is linked to Hepatic fibrosis.