CREB3L3 and steatosis: Similarly, the 42 common downregulated TFs (Figure 4B) include both signatures of steatosis and obesity (CNOT3, CREB3L3, REPIN1, STAT1), and signatures of fibrosis (CCNE1, ETS1, HDAC6, HDAC9, HLF, PLAGL1, SOX4, TRIM16, TRIM29) and hepatocellular carcinoma (HCC) (BCL3, MYCBP, SMARCA4).