According to whether age ≥ 70 years, ECOG ≥ 2, aa‐IPI scores ≥ 2, B symptoms, body mass index (BMI) ≥ 25,16 hypertension or cardiovascular disease, double‐express, elevated β2‐MG, elevated LDH, albumin ≤35 g/L, we divided the whole study population into subgroups. The gene discussed is ALB; the disease is Hypertension.