One might expect that the blood pressure response in male and female rats would differ because fructose‐induced hypertension has been shown to depend on an activated RAS (Farah et al., 2007; Navarro‐Cid et al., 1995) and females are more resistant to the pro‐hypertensive actions of Ang II than are males (Brown et al., 2012; Gillis & Sullivan, 2016; Sampson et al., 2008; Shukri et al., 2018; Xue et al., 2005; Zimmerman & Sullivan, 2013). This evidence concerns the gene AGT and Hypertension.