RUNX2 and nonpapillary renal cell carcinoma: Given that dysregulation of the Wnt/β‐Catenin signaling pathway is also an independent predictor of oncologic results in patients with ccRCC,45 it was discovered that the clone formation, proliferation, and migration ability of ccRCC cells was weakened by RUNX2 knockdown and the Wnt/β‐catenin signaling pathway was also inactivated, while there was an opposite outcome when RUNX2 was upregulated.