BNIP3 and colonic neoplasm: For example, in colon cancer,108 gastric cancer,109 pancreatic cancer110, 111 BNIP3 often appears downregulated, which is thought to be associated with abnormal methylation mediated by DNA‐methyltransferase 3β (DNMT3β) and DNA‐methyltransferase 1 (DNMT1).