These results implied that circ_0008812 and circ_0001583 might modulate breast cancer initiation and development through 4 axes, including miR-4554-3p/RACGAP1, miR-93-5p/KPNA2, miR-6715a-3p/KPNA2 and miR-17-5p/KPNA2. This evidence concerns the gene KPNA2 and breast cancer.