AKT1 and cancer: Triple-negative breast cancer (TNBC) cells with accelerated glycolysis highly express granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) under the regulation of liver-enriched activator protein and AMP-activated protein kinase (AMPK)-serine/threonine-protein kinase (ULK1) pathway, supporting myeloid-derived suppressor cells (MDSCs) development and facilitating CD8+T cell inhibition and cancer progression (Li et al., 2018).