HAVCR2 and myeloid leukemia: TIM-3 is also highly expressed in human myeloid leukemia cells, mediating PI3K-mTOR and hypoxic pathway activation to enhance glycolysis (Prokhorov et al., 2015), In contrast, another study found that glycolytic flux negatively correlates with TIM-3 expression in Jurkat T cells (Lee et al., 2020), so the association between TIM-3 and glycolysis warrants further illustration.