In lung cancer, Nishimaki and others have shown that P2X7-dependent ATP release following RT activates P2Y6 and P2Y12 receptors potentiating the cellular response to DNA damage induced by γ-radiation trough EGFR and ERK1/2 activation (Nishimaki et al., 2012; Ide et al., 2014). This evidence concerns the gene P2RX7 and lung cancer.