Yang et al. demonstrated that TRIM27 could promote the tumorigenesis of breast cancer by cooperating with STK38L to inhibit Unc-51-like kinase 1 (ULK1)-induced autophagy, (Yang et al., 2022), where ULK1 is a cytoplasmic kinase that can interact with the autophagy-related gene 13 (ATG13), and focal adhesion kinase interacting protein 200 kDa (FIP200) to trigger the initiation of autophagy (Amaravadi et al., 2019). Here, TRIM27 is linked to breast cancer.