Lung cancer is a malignant tumor originating from the bronchial mucosa or glands of the lungs (Hirsch et al., 2017; Bray et al., 2018).Non-small-cell lung carcinoma (NSCLC) is the most common type of lung cancer (Fois et al., 2021).In NSCLC, TRIM27 was found to promote the cell proliferation and metastasis in vivo and vitro by interacting with SIX3 and promoting its degradation to activate Wnt/β-catenin signaling (Liu et al., 2020). Here, SIX3 is linked to lung carcinoma.