Chen et al. (2022) reported that TRIM27 was upregulated in the transverse aortic constriction (TAC) group compared to the sham operation (Sham) group, and TRIM27 knockdown could attenuate cardiac hypertrophy in vitro and in vivo. Mechanistically, TRIM27 was found to activate Akt/mTOR signaling by interacting with PTEN (Lee et al., 2013; Chen et al., 2022). The gene discussed is PTEN; the disease is cardiac hypertrophy.