Many studies demonstrated that TRIM27 might contribute to the progression of cancer, ischemia-reperfusion injury, cardiac hypertrophy and brain diseases (Gillot et al., 2009; Zaman et al., 2013; Liu et al., 2014; Conwell et al., 2015; Zheng et al., 2015; Nie et al., 2016; Zhuang et al., 2016; Zhuang et al., 2017; Li Y. et al., 2021; Yang et al., 2022). This evidence concerns the gene TRIM27 and cancer.