Particular attention to surface epithelial dysplasia and tumour morphology (dirty necrosis in the colonic malignancies, cribriform glandular pattern in prostatic malignancies, high-grade cytology of serous carcinoma) along with the use of immunohistochemistry like PSA, SATB homeobox-2 (SATB2) and paired box gene 8 always aids in precise diagnosis [19]. The gene discussed is SATB2; the disease is neoplasm.