In addition, there was a significant association between COVID-19 severity and the haplogroup-specific HIMs of both ACE2-hg1 and ACE2-hg2 (Benjamini-Hochberg (BH)-corrected P < 0.01, OR = 1.60 for the ACE2-hg1-specific variant, OR = 0.63–0.67 for ACE2-hg2-specific variants) (Fig. 4C). This evidence concerns the gene ACE2 and COVID-19.