In Han Chinese female subjects, alleles of both rs2074192 (T) and rs2106809 (A) that were carried by ACE2-hg1 were associated with reduced circulating angiotensin-(1-7) levels [34], which may partially account for the greater blood pressure response to changes in dietary sodium intake in the Chinese population [35] and also be responsible for the increased susceptibility to hypertension [36]. This evidence concerns the gene PKD1P1 and hypertensive disorder.