After binding to PDGF receptors, PDGF ligands stimulate the intracellular signal cascades, e.g., PI3K-Akt, Janus kinase (JAK), mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK), thereby to promote tumor cell proliferation and invasion [33]. Here, WNK2 is linked to neoplasm.