Several studies showed that m7G modification was associated with lung cancer, squamous cell carcinoma of the head and neck, acute myeloid leukemia, and esophageal squamous cell carcinoma in tumor proliferation and progression [12–15], which indicated the key impact of METTL1 and WDR4 on m7G modification in tumors. The gene discussed is METTL1; the disease is lung carcinoma.