We found that eight RNFs including RNF220, RNF25, TRIM25, BMI1, RNF115, TRAIP, RNF157, and RNF19B were overexpressed in HCC cells compared to normal cells by immunohistochemistry (IHC) staining (Figures 6(a)–6(h)). Here, RNF25 is linked to hepatocellular carcinoma.