KPNA2 and breast cancer: Karyopherin alpha 2 (KPNA2, 58 kDa) is one of seven members of the karyopherin α-family [6, 7]; Dysregulation of KPNA2 had been reported serving as a potential biomarker in several malignancies, including breast cancer [8], gastric cancer [9], lung cancer [10], and glioma [11].