In this study, RR (80.33%) in the observation group was substantially elevated than the RR of the control group (62.30%) following the treatment, and the improved levels of CD3+, CD4+, and CD8+ in the observation group were greater than the control group after treatment, implying that microwave ablation in combination with anti-PD-1 monoclonal antibody was superior to the lone use of anti-PD-1 monoclonal antibody for treating the NSCLC and can enhance the patients' cellular immunity in a more effective manner. Here, CD4 is linked to non-small cell lung carcinoma.