For glioma cell lines U87 ΔEGFR, and 251 EGFR VIII, we observed that erlotinib nor luteolin alone at the concentrations tested did not induce significant apoptosis as measured by the expression of cleaved PARP, cleaved caspase, Bcl-xL using Western blot analysis (Figure 5A). The gene discussed is BCL2L1; the disease is central nervous system cancer.